Abreva Cream is the only nonprescription cold sore medicine approved by the FDA to shorten healing time. While other products just soothe, Abreva does more than just reduce the duration of cold sore symptoms like tingling, pain, burning, and/or itching. When used at the first tingle, Abreva can help heal your cold sore in as little as 2½ days. Abreva works quickly by penetrating deep into the skin to the source of the spreading virus. Abreva comes in a tube or pump, and uses the same formula for each. Gender: unisex. Age Group: adult.